Thermo Fisher Scientific eIF3A/eIF3S10 Polyclonal Antibody
Thermo Fisher의 eIF3A/eIF3S10 폴리클로날 항체는 인간 및 마우스 반응성을 가지며, Western blot 및 IP 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공합니다. 연구용으로 단백질 번역 개시 복합체(eIF-3) 연구에 활용됩니다.
- 카탈로그번호
- A302002A
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of human translation initiation factor 3 subunit A (eukaryotic translation initiation factor 3, subunit 10) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat, Zebrafish, and X. tropicalis
Target Information
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi, and eIF-5 to form the 43S pre-initiation complex (43S PIC).
It stimulates mRNA recruitment and scanning for AUG recognition, and is also required for disassembly and recycling of post-termination ribosomal complexes. The eIF-3 complex prevents premature joining of ribosomal subunits and specifically targets mRNAs involved in cell proliferation, differentiation, and apoptosis.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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