Thermo Fisher Scientific Phospho-STAT6 (Thr645) Polyclonal Antibody
인간 STAT6 단백질의 Thr645 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC에 적합하며, Protein A로 정제된 액상 형태. IL-4/IL-13 매개 Th2 면역 반응 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence including phosphorylation site of threonine 645 (P-A-T(p)-I-K) derived from human STAT6 and conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | Dulbecco’s PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL-13. STAT6-deficient (Stat6-/-) models show impaired IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4-mediated proliferation.
STAT6 mRNA is detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta.
STAT6 is critically involved in Th2 immune response and essential for IL-4-mediated biological responses, existing naturally in two isoforms: STAT6a and STAT6c.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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