Thermo Fisher Scientific Phospho-ATF4 (Ser245) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunohistochemistry (IHC)

• Tested Dilution: 1:50–1:100

Product Specifications

Target Information

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein capable of binding a tax-responsive enhancer element in the LTR of HTLV-1. It was also characterized as the cAMP-response element binding protein 2 (CREB-2).
The encoded protein belongs to a family of DNA-binding proteins including the AP-1 family, CREBs, and CREB-like proteins. These transcription factors share a leucine zipper region involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids functioning as a DNA binding domain.
Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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