Thermo Fisher Scientific Ataxin 3 Polyclonal Antibody
Ataxin 3 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(PFA 고정) 실험에 적합하며, 인간, 마우스, 랫트에 반응. 고순도 Affinity chromatography 정제 및 안정적인 PBS/glycerol 저장용액 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ATXN3 (Accession P54252), corresponding to amino acid residues Q230–E280 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899521 |
Product Specific Information
Antibody detects endogenous levels of total Ataxin 3.
Target Information
Machado-Joseph disease (MJD) is an autosomal dominant neurologic disorder, identical to spinocerebellar ataxia-3. The MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region; expansion from normal 13–36 to 68–79 repeats causes the disease. There is a negative correlation between age of onset and CAG repeat numbers. Ataxin-3 interacts with transcription regulators (CBP, p300, and PCAF), represses transcription, and functions as a histone-binding deubiquitinating enzyme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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