Thermo Fisher Scientific ATF6 Polyclonal Antibody
ATF6 단백질을 검출하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. 고순도 affinity chromatography 정제 및 -20°C 보관.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ATF6 (Accession P18850), corresponding to amino acid residues T289–K339 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899522 |
Product Specific Information
Antibody detects endogenous levels of total ATF6.
Target Information
ATF6 is a transcription factor involved in the endoplasmic reticulum (ER) stress response by activating unfolded protein response (UPR) target genes. It binds DNA on specific ER stress response elements (ERSE and ERSE II) and requires NF-Y binding for activity. ATF6 forms homodimers and heterodimers with ATF6 beta, interacting with NF-Y, GTF2I, YY1, and SRF transcription factors. Under ER stress, the cleaved N-terminal domain translocates to the nucleus, functioning as a transcription factor. The protein is N-glycosylated, phosphorylated by MAPK14/P38MAPK, and belongs to the bZIP family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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