Thermo Fisher Scientific M-cadherin Polyclonal Antibody
인간 M-Cadherin(CDH15) 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. 고순도 Protein A 및 항원 친화 크로마토그래피로 정제되었으며, 0.5 mg/mL 농도의 액상 형태로 제공됩니다. 근육세포 분화 연구에 활용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:8000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:10–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 739–767 amino acids from the C-terminal region of human M-Cadherin (CDH15) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2260299 |
Target Information
Cadherins are a multigene family of Ca++-dependent cell adhesion molecules. They are transmembrane glycoproteins consisting of an extracellular domain mediating Ca++-dependent intercellular adhesion by homophilic interactions, a transmembrane region, and a cytoplasmic domain.
The extracellular domain is divided into subdomains EC1–EC5. Homologies among cadherins are most prominent in the cytoplasmic domain and EC1–EC2, less so in EC5 and the transmembrane region. The adhesive binding properties are located in the N-terminal part of the molecules.
Four mammalian cadherins have been identified: neuronal (N), epithelial (E), placental (P), and muscle (M) cadherins. M-cadherin is expressed at low levels in myoblasts and upregulated during myotube formation, indicating its role in skeletal muscle differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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