Thermo Fisher Scientific SMC1 Polyclonal Antibody
SMC1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human 및 Mouse에 반응합니다. Western blot, IHC, IP 등에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용되며 장기 보관 시 -20°C에서 보관합니다.
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Thermo Fisher Scientific SMC1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 308–546 of Human SMC1A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547165 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, Molt-4, NIH-3T3, JC, BCL-1
- Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (89%), Xenopus laevis (96%), Chicken (95%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair, and global transcriptional repression.
SMC proteins are conserved in eukaryotes and are essential for proper mitotic chromosome segregation.
SMC1 and SMC3 form a heterodimeric complex required for metaphase progression and sister chromatid cohesion.
Mutations in the SMC1A gene can lead to Cornelia de Lange syndrome 2.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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