Thermo Fisher Scientific OXER1 Polyclonal Antibody
Rabbit polyclonal antibody against human OXER1 for IHC applications. Recommended antigen retrieval with citrate buffer (pH 6.0). High species identity with human and primates. Supplied as liquid, unconjugated, 1 mg/mL concentration.
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Thermo Fisher Scientific OXER1 Polyclonal Antibody
Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from 1st extracellular domain of human OXER1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 1 month. For long-term storage, store at -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2550420 |
Product Specific Information
In IHC applications, antigen retrieval using a citrate buffer (pH 6.0) is recommended.
Percent identity with other species by BLAST analysis: Human, Gorilla (100%), Monkey (94%), Elephant (83%).
Target Information
TG1019 is a G protein-coupled receptor that functions as a chemoattractant for eosinophils and neutrophils.
TG1019 is expressed in various tissues except the brain, with the highest expression in liver, kidney, peripheral leukocytes, lung, and spleen.
TG1019 interacts with the protein OXE to form TG1019/OXE, a Galpha i/o protein-coupled receptor.
Signals from TG1019 are transduced via a Galpha i/o protein to PLC/calcium, MEK/ERK, and PI3K/Akt pathways.
Stimulation with 5-oxo-6E,8Z,11Z,14Z eicosatetraenoic acid (5-oxo-ETE) induces intracellular calcium mobilization and rapid activation of MEK/ERK and PI3K/Akt pathways.
TG1019 may also play a role in downregulating cAMP production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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