Thermo Fisher Scientific Catenin, beta (p120) Monoclonal Antibody (CTNNB1/2098)
인간 베타-카테닌(CTNNB1)을 인식하는 마우스 모노클로날 항체로, IHC(P), IHC(PFA), Peptide Array 등 다양한 응용에 적합합니다. 단백질 A/G로 정제된 액상 형태이며, 4°C 보관이 권장됩니다. 세포 접착 및 신호전달 연구에 활용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CTNNB1/2098 |
| Immunogen | Recombinant full-length human beta-Catenin (CTNNB1) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Beta-catenin, an adherens junction (AJ) protein, is a key component of cell-cell adhesion structures. AJs are essential for the formation and maintenance of epithelial layers by regulating cell growth and adhesion. Beta-catenin interacts with E-cadherin and alpha-catenin, anchoring the complex to the actin cytoskeleton. It also associates with the adenomatous polyposis coli protein and microtubules, participating in signaling pathways including Wnt/Wingless.
Beta-catenin is expressed in various hair follicle cells and epithelial tissues. Dysregulation is implicated in pilomatrixoma, medulloblastoma, colorectal, ovarian, and other cancers. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, promoting transcription of genes such as cyclin D and c-myc, which drive cell proliferation and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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