Thermo Fisher Scientific PABPC4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Product Specifications

Product Specific Information

Predicted to react with Human and Rat samples.

Target Information

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs.
PABPC4, also known as IPABP (inducible PABP), is an activation-induced T-cell mRNA encoding protein. Activation of T cells increases PABPC4 mRNA levels approximately 5-fold.
PABPC4 contains four RNA-binding domains and a proline-rich C terminus, and is primarily localized to the cytoplasm. It may regulate the stability of labile mRNA species in activated T cells.
PABPC4 was also identified as APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets, and may be involved in protein translation regulation in platelets and megakaryocytes or in polyadenylate binding/stabilization in platelet dense granules.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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