Thermo Fisher Scientific KCNE1L Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Product Specifications

Product Specific Information

Predicted to react with Mouse and Rat samples.

Target Information

Kcne1 is a member of voltage-gated potassium (Kv) channels, which are involved in diverse physiological functions such as neurotransmitter release, heart rate regulation, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume control.
The Kcne1 gene encodes a membrane protein similar to the KCNE1 gene product, a member of the potassium channel, voltage-gated, isk-related subfamily.
Kcne1 is an intronless gene deleted in AMME contiguous gene syndrome and may contribute to cardiac and neurological abnormalities associated with the syndrome.
Functionally, Kcne1 acts as a potassium channel ancillary subunit essential for generating native K(+) currents by forming heteromeric complexes with Kv channel alpha subunits. It also serves as an inhibitory beta-subunit of the cardiac potassium ion channel KCNQ1.
Diseases associated with KCNE1 include Jervell and Lange-Nielsen Syndrome 2 and Long QT Syndrome 5.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.