Thermo Fisher Scientific Nav1.4 Polyclonal Antibody
Nav1.4 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, WB 및 IHC에 사용 가능. 인간, 마우스, 랫트 반응성. 동결건조 형태로 장기 보관 시 -20°C 권장. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from mouse Nav1.4 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen is homologous in human and rat.
Specificity: Nav1.4.
Target Information
Voltage-gated sodium channels are selective ion channels that regulate sodium ion permeability in excitable cells. During action potential propagation, sodium channels allow an influx of sodium ions, rapidly depolarizing the cell.
These channels comprise a pore-forming alpha subunit and two beta subunits (β1 and β2). The beta subunits modulate channel expression, gating, and function as cell adhesion molecules.
Alpha subunits type I and III are mainly expressed in neuronal cell bodies, while type II is more abundant along axons.
Beta1 subunit is expressed in brain, skeletal, and cardiac muscle; β1 and β2 are highly expressed in Purkinje cells, and β1 is found in pyramidal cells of the deep cerebellar nuclei.
Impaired voltage-gated sodium channels are associated with diseases such as myotonia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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