Thermo Fisher Scientific Nav1.7 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:300–1:2,000

Immunohistochemistry (IHC)

• Tested Dilution: 1:300–1:2,000

Miscellaneous (PubMed)

• Publication: View 1 publication

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: SCN9A.

Target Information

Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels.
Members of this superfamily share structural similarity with two short intracellular termini, two transmembrane segments, and a large extracellular loop containing a conserved cysteine-rich region.

There are three homologous isoforms of ENaC (alpha, beta, gamma).
ENaC in kidney, lung, and colon plays a crucial role in trans-epithelial sodium and fluid balance, and mediates aldosterone-dependent sodium reabsorption in the distal nephron, regulating blood pressure.
It is also regulated partly through association with CFTR chloride ion channel.
Gain-of-function mutations in beta or gamma ENaC can cause Liddle’s syndrome (hypertension), while loss-of-function mutations in alpha or beta ENaC cause pseudohypoaldosteronism (PHA-1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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