Thermo Fisher Scientific Nav1.7 Polyclonal Antibody
Nav1.7 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot과 Immunohistochemistry에 적합. SCN9A 특이적이며, 인간 시료 반응성. 동결건조 형태로 제공되며, 장기 보관 시 -20°C에서 안정적. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
Miscellaneous (PubMed)
- Publication: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 1000–1050 of human Nav1.7 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: SCN9A.
Target Information
Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels.
Members of this superfamily share structural similarity with two short intracellular termini, two transmembrane segments, and a large extracellular loop containing a conserved cysteine-rich region.
There are three homologous isoforms of ENaC (alpha, beta, gamma).
ENaC in kidney, lung, and colon plays a crucial role in trans-epithelial sodium and fluid balance, and mediates aldosterone-dependent sodium reabsorption in the distal nephron, regulating blood pressure.
It is also regulated partly through association with CFTR chloride ion channel.
Gain-of-function mutations in beta or gamma ENaC can cause Liddle’s syndrome (hypertension), while loss-of-function mutations in alpha or beta ENaC cause pseudohypoaldosteronism (PHA-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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