Thermo Fisher Scientific Nav1.6 Polyclonal Antibody
Nav1.6(SCN8A) 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 사용 가능. Human, Mouse, Rat 반응성. 동결건조 형태로 제공되며, 4°C 또는 -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 3 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal region of human Sodium channel protein type 8 subunit alpha (SCN8A, Nav1.6) conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in mouse and rat.
- Specificity: SCN8A.
Target Information
The sodium channel protein type 8 subunit alpha (Na⁺ CP type VIII alpha) is a multi-pass transmembrane protein that mediates sodium ion permeability of excitable membranes.
Voltage-gated sodium channels consist of one pore-forming alpha subunit and two beta subunits (β1, β2). The beta subunits regulate expression levels, modulate gating, and act as cell adhesion molecules.
Alpha subunits of sodium channels type I and III are mainly expressed in neuronal cell bodies, while type II alpha subunits are abundant along axons.
Sodium channels are essential for rapid signal transduction and neuronal development.
Defects in the SCN8A gene can cause impaired motoneuron growth, progressive paralysis, and early death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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