Thermo Fisher Scientific CD137/4-1BB/TNFRSF9 Monoclonal Antibody (r4-1BB/4603)
인간 CD137(4-1BB/TNFRSF9)을 인식하는 마우스 단클론 항체. IHC(P) 및 IHC(PFA) 실험에 사용 가능. 단백질 A/G 정제, 200 µg/mL 농도. PBS 완충액에 0.05% BSA 및 sodium azide 포함. 연구용 전용 시약.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 2–4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | r4-1BB/4603 |
| Immunogen | Recombinant fragment (aa 19–188) of human CD137 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD137 (also known as TNFRSF9 or 4-1BB) is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling supports the survival and proliferation of activated and memory T cells, while regulating myelopoiesis and dendritic cell development. Activated CD137 induces cytokine release affecting peripheral monocyte survival. Soluble CD137 forms may act as a negative regulator in immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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