Thermo Fisher Scientific CD137/4-1BB/TNFRSF9 Monoclonal Antibody (4-1BB, 3201)
CD137/4-1BB/TNFRSF9 단클론 항체로 인간 시료에 반응합니다. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합합니다. Protein A/G 정제, 무보존제 PBS 용액 형태로 제공됩니다. 활성화된 T세포 표지 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–4 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4-1BB, 3201 |
| Immunogen | Recombinant fragment (aa 19–188) of human CD137 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody tested in direct ELISA.
- For immunohistochemistry (PFA fixed): incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris Buffer with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
CD137 (also known as TNFRSF9 or 4-1BB) is an inducible costimulatory molecule primarily expressed on activated T cells.
Its ligand, 4-1BBL, is found on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling supports the survival and expansion of activated and memory T cells, while modulating myelopoiesis and dendritic cell development.
Triggered CD137 induces cytokine release that regulates peripheral monocyte survival.
Soluble CD137 may provide a negative feedback mechanism in immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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