Thermo Fisher Scientific KLF10 Monoclonal Antibody (3A10)
KLF10 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, Western blot 및 ELISA에 적합합니다. 인간 시료 반응성이 있으며, TGF-β 신호 조절 연구에 활용됩니다. PBS 용액 상태로 제공되며, -20°C에서 보관합니다.
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- H00007071-M74
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3A10 |
| Immunogen | KLF10 (AAH11538.1, 111 a.a. ~ 210 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
LSDTAKPHIA APFKEEEKSP VSAPKLPKAQ ATSVIRHTAD AQLCNHQTCP MKAASILNYQ NNSFRRRTHL NVEAARKNIP CAAVSPNRSK CERNTVADVD
Target Information
KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. It acts as a transcriptional repressor regulating cell growth and apoptosis. KLF10 binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta, linking TGF-beta-mediated signaling to pancreatic epithelial cell growth regulation. Ubiquitous expression is observed across tissues. Overexpression may be associated with renal clear cell carcinoma and other tumors. KLF11, a related zinc finger transcription factor, binds SP1-like sequences, inhibiting cell growth and inducing apoptosis; defects in KLF11 cause maturity-onset diabetes of the young type 7 (MODY7).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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