Thermo Fisher Scientific KLF10 Monoclonal Antibody (8F12)
Human KLF10 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Western blot 및 ELISA에 적합. Affinity chromatography로 정제된 액상 형태이며, 보존제가 포함되지 않음. TGF-beta 관련 세포 성장 조절 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8F12 |
| Immunogen | KLF10 (AAH11538.1, 111–210 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
LSDTAKPHIA APFKEEEKSP VSAPKLPKAQ ATSVIRHTAD AQLCNHQTCP MKAASILNYQ NNSFRRRTHL NVEAARKNIP CAAVSPNRSK CERNTVADVD
Target Information
KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. It functions as a transcriptional repressor involved in regulating cell growth and apoptosis. KLF10 binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta, linking TGF-beta-mediated signaling to pancreatic epithelial cell growth regulation. It may inhibit Smad7 expression and is ubiquitously expressed in most tissues. Overexpression of KLF10 has been associated with renal clear cell carcinoma and other cancers. KLF11, a related zinc finger transcription factor, binds SP1-like sequences and is implicated in MODY7 diabetes.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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