Thermo Fisher Scientific KLF10 Monoclonal Antibody (6E8)
KLF10 단백질을 표적으로 하는 Mouse IgG2a 단일클론 항체로, Human 시료에 반응합니다. Western blot 및 ELISA에 적합하며, 높은 특이성과 재현성을 제공합니다. TGF-β 신호 관련 세포 성장 조절 연구에 활용됩니다.
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- H00007071-M64
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Thermo Fisher Scientific KLF10 Monoclonal Antibody (6E8)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6E8 |
| Immunogen | KLF10 (AAH11538.1, 111–210 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
LSDTAKPHIA APFKEEEKSP VSAPKLPKAQ ATSVIRHTAD AQLCNHQTCP MKAASILNYQ NNSFRRRTHL NVEAARKNIP CAAVSPNRSK CERNTVADVD
Target Information
KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. It acts as a transcriptional repressor regulating cell growth and apoptosis. KLF10 binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta, linking TGF-beta-mediated signaling to pancreatic epithelial cell growth regulation. It may inhibit Smad7 expression in bronchial epithelial cells and is expressed ubiquitously in most tissues. Overexpression of KLF10 is associated with renal clear cell carcinoma and other tumors.
KLF11, a related zinc finger transcription factor, binds SP1-like sequences and is implicated in cell growth inhibition and apoptosis. Defects in KLF11 are associated with maturity-onset diabetes of the young type 7 (MODY7).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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