Thermo Fisher Scientific AKAP8 Polyclonal Antibody
AKAP8 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC(P), ICC/IF에 적합합니다. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS, 40% glycerol 완충액에 보관되며 연구용으로만 사용 가능합니다.
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- PA552103
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human AKAP8. Recombinant protein control fragment (Product #RP-102489). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2637816 |
Product Specific Information
Immunogen sequence:
PEMEGDDNLG GEDKKETPEE VAADVLAEVI TAAVRAVDGE GAPAPESSGE PAEDEGPTDT AEAGSDPQAE QLLEEQVPCG TAHEKGVPKA RSEAAEAGNG AETMAAEAES AQTRVAPAPA AADAEVEQTD AESKDAVP
Highest antigen sequence identity to orthologs:
- Mouse: 53%
- Rat: 58%
Target Information
The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins (AKAPs).
AKAP95 (AKAP8) is a nuclear matrix protein expressed in liver, heart, pancreas, kidney, and skeletal muscle. During mitosis, AKAP95 is recruited to chromosomes and plays an essential role in mitotic progression. It participates in PKA signaling through interaction with the RII regulatory subunit and forms a complex with HA95 and HDAC3, required for Histone H3 deacetylation during mitosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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