Merck MISSION Lenti microRNA Inhibitor, Mouse
Tough Decoy(TuD) 디자인 기반의 렌티바이러스 miRNA 억제제. 다양한 세포 유형에 효율적으로 전달 가능. 장기적 miRNA 억제 효과 제공. 퓨로마이신 내성 유전자를 포함하여 안정적 세포 선택 가능.
- 카탈로그번호
- MLTUD0023
- 브랜드
- Merck Sigma
- 카테고리
- RNA/DNA Reagents
- 판매단위
- pk
카탈로그
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MISSION® Lenti microRNA Inhibitor, Mouse
mmu-miR-101a-3p
Tough Decoy (TuD)
제품 정보
| 항목 | 내용 |
|---|---|
| Quality Level | 200 |
| 제품 라인 | MISSION® |
| 형태 (Form) | Liquid |
| 농도 (Concentration) | ≥1×10⁶ VP/ml (via p24 assay) |
| 성숙 서열 (Mature Sequence) | UACAGUACUGUGAUAACUGAA |
| Sanger 성숙/소수 수납 번호 | MIMAT0000133 |
| microRNA 수납 번호 | MI0000148 |
| 배송 상태 | Dry ice |
| 저장 온도 | −70°C |
제품 설명
Individual lenti microRNA inhibitors are designed using a proprietary algorithm based on the work of Haraguchi, T. et al., in collaboration with Dr. Hideo Iba (University of Tokyo).
This algorithm utilizes the Tough Decoy (TuD) design to effectively inhibit target miRNA activity.
miRNA are known to regulate gene expression through translational repression, mRNA cleavage, and deadenylation.
The lentiviral microRNA inhibitors are cloned into the TRC2-pLKO-puro vector.
Co-transfection with compatible packaging plasmids produces viral particles suitable for mammalian cell transduction.
The vector includes the Woodchuck Hepatitis Post-Transcriptional Regulatory Element (WPRE) for enhanced transgene expression and a puromycin resistance gene for selection of successfully transduced cells.
주요 특징
- Potent inhibition of desired miRNA
- Efficient delivery into a wide variety of cell types via lentiviral system
- Enables long-term inhibition without repeat transfection
- Includes puromycin resistance for stable cell selection
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