Merck R-Spondin3/RSPO3(22-146) human

R-Spondin3/RSPO3(22-146) human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

THSD2, CRISTIN1, PWTSR

생물학적 소스

human

재조합

expressed in HEK 293 cells

태그

6-His tagged (C-terminus)

assay

≥95% (SDS-PAGE)

form

lyophilized

분자량

calculated mol wt 15.3 kDa
observed mol wt 18 kDa (DTT-reduced. Protein migrates due to glycosylation. Gln 22 is the predicted N-terminal.)
observed mol wt 24 kDa

포장

pkg of 10 μg

불순물

<1 EU/μg endotoxin (LAL test)

UniProt 수납 번호

Q9BXY4

배송 상태

wet ice

저장 온도

−20°C

Gene Information

human ... RSPO3(84870)

R-Spondin 3 (RSPO3), also called cysteine-rich and single thrombospondin domain containing-1 (CRISTIN1), Protein with TSP type-1 repeat (PWTSR), is a member of the R-Spondin protein family. R-spondins (RSPO) are a recently discovered secretory protein family with four members in human and mouse. Although all four RSPO proteins activate the canonical Wnt pathway, RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. RSPO-3 is expressed ubiquitously and expressed at higher level in placenta, small intestine, fetal thymus and lymph node. RSPO3 is the activator of the β-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO3 acts both in the canonical Wnt/β-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. RSPO3 also acts as a ligand for frizzled FZD8 and LRP6 and may negatively regulate the TGF-β pathway.