Merck IL-36β mouse

IL-36β mouse

recombinant, expressed in E. coli, untagged, >95% (SDS-PAGE)

Interleukin-1 family member 8, Sentrin-specific protease 2, Interleukin-36β

생물학적 소스

mouse

재조합

expressed in E. coli

결합

untagged

assay

>95% (SDS-PAGE)

form

lyophilized

분자량

~17 kDa

포장

pkg of 10 μg

불순물

<0.01 EU/μg endotoxin, tested

색상

white

UniProt 수납 번호

Q9D6Z6

배송 상태

wet ice

저장 온도

−20°C

Gene Information

mouse ... Il36b(69677)

IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.