Merck IFN-ω human

IFN-ω human

recombinant, expressed in HEK 293 cells, ≥93% (SDS-PAGE)

IFNG, IFI

생물학적 소스

human

재조합

expressed in HEK 293 cells

assay

≥93% (SDS-PAGE)

form

lyophilized powder

분자량

calculated mol wt 16.8 kDa (no tag)
observed mol wt 25.0 kDa (DTT-reduced. Protein migrates due to glycosylation. Gln 24 is the predicted N-terminus.)

포장

pkg of 10 μg

불순물

<1 EU/μg endotoxin (LAL test)

UniProt 수납 번호

P01579

배송 상태

wet ice

저장 온도

−20°C

Gene Information

human ... IFN-gamma(3458)

Interferon-gamma (IFN-γ/IFNG) is a dimerized soluble cytokine that is the only member of the type II class of interferon. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-γ belongs. IFN-gamma has been used in a wide variety of clinical indications. Interferon-gamma (IFN gamma) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFNG that reflect the resistance of these cells to IFNG-mediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression.