Merck IL-17E human

IL-17E human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Interleukin-25, IL-25, IL-17E

생물학적 소스

human

재조합

expressed in HEK 293 cells

태그

6-His tagged (C-terminus)

assay

≥95% (SDS-PAGE)

form

lyophilized powder

분자량

calculated mol wt 16.7 kDa
observed mol wt 27 kDa
observed mol wt 31 kDa
observed mol wt 4 kDa (DTT-reduced. Protein migrates due to different glycosylation.Tyr 33 is the predicted N-terminus .)

포장

pkg of 10 μg

불순물

<1 EU/μg endotoxin (LAL test)

UniProt 수납 번호

Q9H293

배송 상태

wet ice

저장 온도

−20°C

Gene Information

human ... IL-17E(64806)

Interleukin 25 (IL25) also known as Interleukin-17E (IL-17E), is a distinct member of the IL17 cytokine family comprised of at least six members sharing a conserved cysteine-knot structure but divergent at the N-terminus. IL-25 is secreted by type 2 helper T cells (Th2) and mast cells. IL25 can induce NF-κB activation, and stimulate the production of IL8. Both this cytokine and IL17B are ligands for the cytokine receptor IL17RB. IL-25 induces the production of other cytokines, including IL-4, IL-5 and IL-13 in multiple tissues, which stimulate the expansion of eosinophils. This cytokine is an important molecule controlling immunity of the gut and has been implicated in chronic inflammation associated with the gastrointestinal tract. IL-25 can kill some types of breast cancer cells.