Merck IL-36β human

IL-36β human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

IL-1F8, IL-1H2, IL-1 eta

생물학적 소스

human

재조합

expressed in E. coli

assay

≥98% (SDS-PAGE)

form

lyophilized powder

분자량

17.3 kDa

포장

pkg of 10 and 50 μg

불순물

<1 EU/μg endotoxin (LAL test)

UniProt 수납 번호

Q9UBH0

배송 상태

wet ice

저장 온도

−20°C

Gene Information

human ... IL36B(26525)

The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36β is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36β signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36β also functions as an agonist of NF-kappaB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36β is a 17.3 kDa protein containing 154 amino acid residues.