Merck IL-22 human

IL-22 human

recombinant, expressed in HEK 293 cells (Ala 34 - Ile 179), ≥95% (SDS-PAGE)

IL-TIF, ZCYTO18

생물학적 소스

human

재조합

expressed in HEK 293 cells (Ala 34 - Ile 179)

태그

His tagged

assay

≥95% (SDS-PAGE)

form

lyophilized powder

분자량

calculated mol wt 17.6 kDa (a polyhistidine tag at the N-terminus.)
observed mol wt 21-33 kDa (DTT-reduced protein.Protein migrates as 21-33 kDa in a SDS-PAGE due to glycosylation.
)

포장

pkg of 10 μg

불순물

<1 EU/μg (LAL test)

UniProt 수납 번호

Q9GZX6

배송 상태

wet ice

저장 온도

−20°C

Gene Information

human ... IL22(50616)

Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.