Merck Complement C2 deficient serum human

Complement C2 deficient serum human

for complement assays

Quality Level

200

생물학적 소스

human

form

liquid

technique(s)

activity assay: suitable

UniProt 수납 번호

P06681

배송 상태

dry ice

저장 온도

−70°C

Gene Information

human ... C2(717)

C2 is a critical protease for compliment activation, which supports bacterial killing via phagocytes. C2 can be used in research to explore the mechanisms by which bacterial pathogens evade detection by the compliment system. One such mechanism by the bacteria Pseudomonas aeruginosa, uses the alkaline protease (AprA) to degrade and cleave C2 which ultimately interferes with the classical and lectin pathways. Research has shown that C2 deficiency results in an increased risk of infection by Streptococcus pyogenes through impaired phaogocytosis and neutrophil dependent killing.