Thermo Fisher Scientific CD10 Recombinant Mouse Monoclonal Antibody (FR4D11)
CD10 단백질을 인식하는 Mouse Recombinant Monoclonal Antibody (Clone FR4D11). Western blot, IHC, ICC/IF, Flow Cytometry 등 다양한 응용 가능. HEK293 발현 시스템 기반, Protein A 정제, PBS buffer에 0.02% ProClin 300 포함. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | FR4D11 |
| Immunogen | This antibody was raised by immunizing mice with Raji cells. Target Family: CD10 (UniProt ID: P08473-1, NCBI Node ID: 9606, Antigen Range: 1–750) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_3074706 |
Product Specific Information
Specificity: FR4D11 antibody recognizes CD10, a cell surface enzyme with neutral metalloendopeptidase activity that inactivates various biologically active peptides.
CD10 is expressed on lymphoblastic, Burkitt’s, and follicular germinal center lymphoma cells, and on cells from patients with chronic myelocytic leukemia (CML).
Target Information
CD10 (Common Acute Lymphocytic Leukemia Antigen, CALLA) is a cell surface enzyme with neutral metalloendopeptidase activity that inactivates a variety of biologically active peptides.
It is expressed on lymphoblastic, Burkitt’s, and follicular germinal center lymphoma cells, immature B cells in adult bone marrow, and on cells from patients with CML.
CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, and highly expressed on kidney and gut epithelial brush borders.
As a neutral endopeptidase, CD10 cleaves peptides at the amino side of hydrophobic residues and inactivates peptide hormones such as glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
It is a 100 kDa type II transmembrane glycoprotein encoded by a single-copy gene (>45 kb), with four alternatively spliced mRNA transcripts that do not affect the coding region.
Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot-Marie-Tooth disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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