Thermo Fisher Scientific HIV1 gp120 (group M, subtype CRF07_BC) Recombinant Rabbit Monoclonal Antibody (001)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:5,000–1:10,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for HIV-1 gp120 (group M, subtype CRF07_BC).

Target Information

Human immunodeficiency virus type 1 (HIV-1) entry into target cells is mediated by envelope (Env) glycoproteins, which form trimers consisting of gp120/gp41 complexes. The gp120 subunit initiates the entry process by interacting sequentially with the CD4 receptor and co-receptor CCR5 or CXCR4, inducing conformational changes that allow gp41 to mediate membrane fusion. Cleavage of Env into gp120 and gp41 is essential for activation of its fusogenic activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.