Thermo Fisher Scientific LXR alpha Polyclonal Antibody

Thermo Fisher Scientific LXR alpha Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1:1,000–1:10,000

Product Specifications

Product Specific Information

• Recommended positive controls: HeLa, HepG2, HCT116
• Predicted reactivity: Mouse (86%), Rat (86%), Pig (85%), Rabbit (86%), Bovine (85%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) converts RXR from a silent DNA-binding partner to an active ligand-binding subunit, mediating retinoid responses through LXRES.
LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides.
NR1H3 plays a key role in cholesterol homeostasis, regulating cholesterol uptake via MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8, and interacts with RORA for liver metabolism gene regulation.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음, OCR 텍스트 통합 완료)