Thermo Fisher Scientific Arginase 1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–3 µg/mL
• Publications: View 1 publication

Immunocytochemistry (ICC/IF)

• Tested Dilution: 10 µg/mL
• Publications: View publication

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation.
By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production.

In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported.
In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a).

Arginase-1 may be expressed in myeloid cells infiltrating tumors and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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