Thermo Fisher Scientific Arginase 1 Polyclonal Antibody
Thermo Fisher Scientific의 Arginase 1 Polyclonal Antibody는 마우스 및 랫트 반응성을 가진 염소 유래 IgG 항체입니다. Western blot과 Immunocytochemistry에 적합하며, 액상 형태로 제공됩니다. 0.5 mg/mL 농도, TBS buffer(0.5% BSA 포함)로 안정화되어 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–3 µg/mL
- Publications: View 1 publication
Immunocytochemistry (ICC/IF)
- Tested Dilution: 10 µg/mL
- Publications: View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (NHKPETDYLKPPK) corresponding to the C-terminus amino acids of Arg1 (aa 311–323) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10980832 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation.
By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production.
In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported.
In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a).
Arginase-1 may be expressed in myeloid cells infiltrating tumors and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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