Thermo Fisher Scientific Arginase 1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.01–0.03 µg/mL

Product Specifications

Product Specific Information

• Predicted to react with canine based on sequence homology.
• Tested in Peptide ELISA: antibody detection limit dilution 2,000.

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins from protein degradation.
By degrading arginine, Arginase 1 deprives nitric oxide synthase of its substrate and down-regulates nitric oxide production.
In both human and mouse, Arginase 1 is expressed in liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells.
In humans, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, Arginase 1 expression is a hallmark of alternatively activated macrophages (M2a).
Arginase-1 may be expressed in myeloid cells infiltrating tumors and is typically found in most hepatocellular carcinomas.
Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)