Thermo Fisher Scientific SMN1/SMN2 Polyclonal Antibody
인간 SMN1/SMN2 단백질을 인식하는 염소 유래 폴리클로날 항체로, Western blot 등에 사용 가능. 0.5 mg/mL 농도의 액상 형태이며, TBS 버퍼와 BSA 포함. 스플라이스좀 관련 단백질 연구 및 척수성 근위축증(SMA) 연구에 적합.
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Applications
- Western Blot (WB): 0.3–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (DESENSRSPGNKSDN) corresponding to the internal amino acids of SMN1/SMN2 (aa 168–182) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10980120 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
The SMN1 gene is part of a 500 kb inverted duplication on chromosome 5q13.
This region contains multiple genes and repetitive elements, making it prone to rearrangements and deletions.
Both telomeric and centromeric copies encode the same survival motor neuron (SMN) protein, which plays a catalytic role in the assembly of small nuclear ribonucleoproteins (snRNPs), essential components of the spliceosome.
Mutations in the SMN1 gene are known to cause spinal muscular atrophy (SMA) types 1 and 2.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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