Thermo Fisher Scientific LIF Polyclonal Antibody
Thermo Fisher Scientific의 LIF Polyclonal Antibody는 Mouse 및 Rat에 반응하는 Goat 유래 IgG 항체입니다. Western blot 및 Peptide ELISA에 적합하며, 0.5 mg/mL 농도의 액상 형태로 제공됩니다. LIF 단백질 연구 및 줄기세포 분화 억제 관련 연구에 활용됩니다.
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- PA5142992
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–1.5 µg/mL
- Publications: 참고 문헌 없음
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence: TPVNATCAIRHP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933632 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Target Information
Leukemia inhibitory factor (LIF) is a 20 kDa protein belonging to the IL-6 receptor family. It binds to a heterodimeric membrane receptor composed of a LIF-specific subunit (gp190 or LIFR) and gp130, which is shared among other IL-6 family members.
LIF expression occurs in various tissues such as thymus, lung, and neuronal tissue. It can be upregulated by pro-inflammatory cytokines including TNFα and IL-17. Elevated LIF levels have been observed in rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis.
LIF is best known for inhibiting embryonic stem cell differentiation in mice and promoting stem cell self-renewal. Human and mouse LIF share 79% sequence homology and exhibit cross-species activity, though stem cell differentiation inhibition is mouse-specific.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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