Thermo Fisher Scientific TIP47 Polyclonal Antibody
Human TIP47 단백질을 인식하는 염소 유래 다클론 항체로, Western blot에 적합하며 모든 보고된 isoform을 인식합니다. 액상 형태, 0.5 mg/mL 농도, TBS 버퍼에 보존되며 연구용으로 사용됩니다.
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- PA5142995
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Thermo Fisher Scientific TIP47 Polyclonal Antibody
Applications
- Western Blot (WB): 0.03–0.1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-TRGAVQSGVDKTKS (aa 154–167) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933635 |
Product Specific Information
- Expected to recognize all reported isoforms (NP_005808.3; NP_001157661.1; NP_001157666.1).
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
TIP47 is a cargo protein involved in trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex.
Mannose 6-phosphate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and return to the Golgi complex.
This protein interacts with cytoplasmic domains of both cation-independent and cation-dependent MPRs and is required for endosome-to-Golgi transport.
TIP47 binds directly to GTPase RAB9, increasing affinity for cargo.
It is localized in milk fat globule membranes of human and bovine origin, and is also described as a placental protein.
Elevated levels are found in circulation of cervix carcinoma patients, suggesting its potential role as an oncodevelopmental marker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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