Thermo Fisher Scientific GEMIN2 Monoclonal Antibody (OTI6G4), TrueMAB
GEMIN2 단백질을 인식하는 마우스 모노클로날 항체로, Western blot에 최적화되어 있습니다. 인간, 마우스, 랫트 반응성을 가지며, 동결건조 형태로 제공됩니다. 연구용으로만 사용되며, SMN 복합체 관련 단백질 분석에 적합합니다.
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Thermo Fisher Scientific GEMIN2 Monoclonal Antibody (OTI6G4), TrueMAB
Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6G4 |
| Immunogen | Full length human recombinant protein of human SIP1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
- For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
SIP1 is one of the proteins found in the SMN complex, which consists of the survival of motor neuron (SMN) protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and pre-mRNA splicing. SIP1 interacts directly with SMN and is required for formation of the SMN complex.
A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. However, knockdown of SIP1 mRNA in motor neurons showed normal motor axons, while knockdown of SMN mRNA caused abnormal motor axon outgrowth, indicating that SIP1 may have additional roles outside the SMN complex.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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