Thermo Fisher Scientific GEMIN2 Monoclonal Antibody (OTI4A2), TrueMAB

Applications

• Western Blot (WB): 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform additional desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

SIP1 is one of the proteins found in the SMN complex, which includes the survival of motor neuron (SMN) protein and several gemin proteins.
The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and pre-mRNA splicing.
SIP1 interacts directly with SMN and is required for SMN complex formation.
A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
However, knockdown of SIP1 mRNA in motor neurons showed normal motor axons, while SMN mRNA knockdown caused abnormal axon outgrowth, suggesting SIP1 may have additional roles outside the SMN complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.