Thermo Fisher Scientific Phospho-p130Cas (Tyr165) Polyclonal Antibody
인간 p130Cas의 Tyr165 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin) 적용 가능. 액상 형태, 1 mg/mL 농도, -20°C 보관. 세포 신호전달 및 인산화 연구용.
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Thermo Fisher Scientific Phospho-p130Cas (Tyr165) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human p130Cas around the phosphorylation site of Tyr165 (D-L-YP-Q-V) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554978 |
Target Information
The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signaling via v-Crk and v-Src oncoproteins.
p130Cas contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich region.
It is involved in various biological processes including:
- Cell adhesion and migration
- Growth factor stimulation
- Cytokine receptor engagement
- Bacterial infection
Physiological functions of p130Cas include cardiovascular development, actin filament assembly, and Src-induced cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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