Thermo Fisher Scientific JIP1 Monoclonal Antibody (OTI1D9)
JIP1 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 IHC(Paraffin)에서 사용 가능. 인간 시료 반응성. 고순도 친화 크로마토그래피 정제. 안정한 액상 형태로 -20°C 보관.
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Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D9 |
| Immunogen | Full length human recombinant protein of MAPK8IP1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724539 |
Target Information
The protein encoded by this gene regulates pancreatic beta-cell function and is highly similar to JIP-1, a mouse protein involved in the regulation of c-Jun amino-terminal kinase (MAPK8). It prevents MAPK8-mediated activation of transcription factors and reduces IL-1 beta and MEKK1-induced apoptosis in pancreatic beta cells. Additionally, it acts as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) represses expression of this gene in insulin-secreting beta cells. Mutations have been associated with type 2 diabetes susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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