Thermo Fisher Scientific LEF1/TCF1 alpha (Transcription Factor) Recombinant Rabbit Monoclonal Antibody (LEF1/9403R)
LEF1/TCF1 alpha 전사인자에 특이적인 재조합 토끼 단클론 항체. 인체 시료에 반응하며 IHC(P)에서 사용 가능. CHO 세포 발현, Protein A/G 정제, 4°C 보관. Wnt 신호전달 및 세포 분화 연구에 적합.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | LEF1/9403R |
| Immunogen | Recombinant fragment (around aa1–200) of human LEF1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human tonsil and thymus
- Cellular Location: Nucleus
Target Information
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1.
The encoded protein binds to a functionally important site in the T-cell receptor-alpha enhancer, conferring maximal enhancer activity.
It is involved in the Wnt signaling pathway and may function in hair cell differentiation and follicle morphogenesis.
Mutations in this gene have been found in somatic sebaceous tumors and other cancers, including androgen-independent prostate cancer.
Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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