Thermo Fisher Scientific FOXO1 Monoclonal Antibody (7H3)
FOXO1 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot, IHC, ICC/IF 등 다양한 응용 가능. 인간 시료 반응성, 단백질 G 정제, PBS 용액 형태로 제공되며 보존제가 없음. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 0.1–2 µg/mL | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7H3 |
| Immunogen | Amino acids 242–655 of FKHR expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at −20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_558993 |
Product Specific Information
Predicted molecular weight of approximately 70 kDa. Positive control: Cos 1 cells transfected with human FKHR suggested.
Target Information
FOXO1 (FKHR, Forkhead Box O1) is a transcription factor belonging to the forkhead family. It functions as both coactivator and corepressor of nuclear receptor activity through the LXXLL motif in its C-terminal region. Association of FOXO1 with PAX3 has been linked to alveolar rhabdomyosarcoma. FOXO1 plays roles in autophagy, myogenic differentiation, and tumor suppression. It is a key target of insulin signaling, regulating metabolic homeostasis and oxidative stress response. FOXO1 binds to insulin response elements (IRE) and Daf-16 family binding elements (DBE). It regulates redox balance, osteoblast numbers, bone mass, and endocrine function of the skeleton in glucose metabolism. In hepatocytes, it promotes gluconeogenesis by activating genes such as IGFBP1, G6PC, and PPCK1 in cooperation with PPARGC1A. FOXO1 also acts downstream of CDK1, PKB/AKT1, and SKT4/MST1 in regulating cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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