Thermo Fisher Scientific p21 Polyclonal Antibody
Thermo Fisher Scientific의 p21 Polyclonal Antibody는 인간 및 생쥐 시료에 반응하며, WB·IHC·ELISA·IP 등 다양한 응용에 적합합니다. CDKN1A/p21CIP1 단백질을 타겟으로 하며, 액상 형태로 제공되고 -20°C에서 보관합니다. 종양 억제 단백질 연구에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5 µg–4 µg antibody for 200 µg–400 µg extracts |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–164 of human CDKN1A/p21CIP1 (NP_000380.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914399 |
Product Specific Information
Positive test controls include MCF7, 293T, mouse large intestine, mouse spleen, and rat lung.
The target is usually found in the cytoplasm and nucleus.
Immunogen Sequence:
MSEPAGDVRQ NPCGSKACRR LFGPVDSEQL SRDCDALMAG CIQEARERWN FDFVTETPLE GDFAWERVRG LGLPKLYLPT GPRRGRDELG GGRRPGTSPA LLQGTAEEDH VDLSLSCTLV PRSGEQAEGS PGGPGDSQGR KRRQTSMTDF YHSKRRLIFS KRKP
Target Information
Protein p21 is a tumor suppressor protein that inhibits Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53.
It plays a crucial role in the cellular response to genotoxic stress and DNA damage repair.
- In the nucleus: binds and inhibits CDK1/CDK2, blocking G1→S and G2→M transitions.
- In the cytoplasm: exhibits anti-apoptotic effects by inhibiting caspase 3, ASK1, and JNK.
P21 has dual roles in carcinogenesis, functioning as both a tumor suppressor and oncogene depending on cellular context.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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