Thermo Fisher Scientific FPR1 Polyclonal Antibody
Thermo Fisher Scientific의 FPR1 Polyclonal Antibody는 랫트 FPR1 단백질을 인식하는 토끼 유래 폴리클로날 항체입니다. Western blot 및 IHC에 적합하며, 비결합형 형태로 제공됩니다. 연구용으로 염증 반응 및 면역세포 이동 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 160–220 of rat FPR1 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: FPR1.
Target Information
FPR1 is a member of chemoattractant/chemokine GPCRs expressed mainly on leukocytes, neutrophils, and monocytes.
It is a seven-transmembrane, pertussis toxin-sensitive GPCR that binds to formylated peptides generated by bacteria, resulting in leukocyte trafficking to inflammation sites.
Ligand binding to FPR activates multiple effectors including phospholipase C, leading to calcium mobilization and PKC activation.
FPR signaling is also involved in actin cytoskeleton polarization, integrin activation, cell migration, phagocytosis, degranulation, and release of reactive oxygen intermediates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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