Thermo Fisher Scientific Phospho-RAD17 (Ser646) Polyclonal Antibody
RAD17 단백질의 Ser646 인산화 형태를 특이적으로 검출하는 폴리클로날 항체. Western blot, IHC, ICC/IF에 사용 가능. 사람, 생쥐, 랫트 반응성. 고순도 정제 및 안정적 저장용 PBS/glycerol buffer 제공. 연구용 전용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human RAD17 (Accession O75943), corresponding to amino acid residues around phosphorylated Ser646 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817429 |
Product Specific Information
Antibody detects endogenous levels of RAD17 only when phosphorylated at Ser646.
Target Information
Rad17 is essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. It has weak ATPase activity required for binding to chromatin. Rad17 participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. It may also serve as a sensor of DNA replication progression and be involved in homologous recombination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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