Thermo Fisher Scientific Phospho-RAD51 (Thr309) Polyclonal Antibody
RAD51 단백질의 Thr309 인산화 형태를 특이적으로 검출하는 폴리클로날 항체로, Western blot 및 Immunocytochemistry에 적합. 인간, 생쥐, 비인간 영장류 반응성. 액상 형태, 1 mg/mL 농도, PBS/glycerol 버퍼. 연구용으로 DNA 복구 메커니즘 연구에 활용 가능.
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- PA5106033
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RAD51 (Accession Q06609), corresponding to amino acid residues around phosphorylated Thr309 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817432 |
Product Specific Information
Antibody detects endogenous levels of RAD51 only when phosphorylated at Thr309.
Target Information
RAD51 plays a critical role in homologous strand exchange, a key step in DNA repair through homologous recombination.
It binds to single- and double-stranded DNA and exhibits DNA-dependent ATPase activity.
RAD51 catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template.
It binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments essential for homology search and strand exchange.
Mutations in the gene can result in breast cancer, mirror movements 2, and Fanconi anemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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