Thermo Fisher Scientific Phospho-PTP1B (Tyr66) Polyclonal Antibody
PTP1B 단백질의 Tyr66 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal 항체. Western blot과 Immunocytochemistry에 적합. 인간, 생쥐, 랫트 반응성. 고순도 정제, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PTPN1 (Accession P18031), corresponding to amino acid residues around phosphorylated Tyr66 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817428 |
Product Specific Information
This antibody detects endogenous levels of PTP1B only when phosphorylated at Tyr66.
Target Information
PTP1B (PTPN1) is a tyrosine-protein phosphatase that regulates endoplasmic reticulum unfolded protein response. It mediates dephosphorylation of EIF2AK3/PERK, inactivating its kinase activity. PTP1B also participates in CKII- and p60c-src-induced signal transduction cascades, regulates EFNA5-EPHA3 signaling affecting cell organization and repulsion, and modulates hepatocyte growth factor receptor (MET) signaling through dephosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-106029_PTP1B_P18031-1_Rabbit.svg, PA5-106029_PTP1B_P18031-1_Rabbit_PDP.jpeg)
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