Thermo Fisher Scientific FKBP1A Monoclonal Antibody (OTI3B3), TrueMAB
Human FKBP1A 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI3B3). Western blot, IHC, Flow Cytometry에 적합. Lyophilized 형태로 제공되며, PBS 기반 buffer에 8% trehalose 포함. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B3 |
| Immunogen | Full length human recombinant protein of human FKBP1A produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of about 1 mg/mL.
- For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
FKBP12 (FKBP1A) is a member of the immunophilin protein family, involved in immunoregulation and basic cellular processes such as protein folding and trafficking.
It functions as a cis-trans prolyl isomerase that binds immunosuppressants FK506 and rapamycin.
FKBP12 interacts with several intracellular signaling proteins, including type I TGF-beta receptor and intracellular calcium release channels, and coordinates multi-protein complex formation of the skeletal muscle ryanodine receptor.
In mouse, deletion of this gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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