Thermo Fisher Scientific MARCH8 Polyclonal Antibody
MARCH8 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체입니다. Western blot 및 Immunocytochemistry에 적합하며, 인간·마우스·랫트 반응성을 보입니다. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도로 PBS에 보관됩니다.
- 카탈로그번호
- PA520632
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–1 µg/mL | View 2 publications |
| Immunocytochemistry (ICC/IF) | 2.5 µg/mL | — |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid peptide from near the carboxy terminus of human MARCH8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157657 |
Product Specific Information
- Suggested positive control: HeLa cell lysate
- PA5-20632 can be used with blocking peptide PEP-0752.
Target Information
MARCH8 (c-MIR) is a novel E3 ubiquitin ligase belonging to the modulator of immune recognition (MIR) family, with a variant RING domain (RING-CH domain).
It acts as a functional and structural homolog of KSHV MIR1 and MIR2, targeting B7-2 for lysosomal degradation and down-regulating its surface expression via ubiquitination.
MARCH8 also down-regulates transferrin receptor and Fas expression, contributing to apoptosis regulation.
It is the first known E3 ubiquitin ligase capable of inhibiting MHC II expression.
Recent studies suggest MARCH8 regulates immune responses by promoting ubiquitination and endocytosis of MHC-II and CD86.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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