Thermo Fisher Scientific BUB1B Monoclonal Antibody (2G9)
Thermo Fisher Scientific의 BUB1B Monoclonal Antibody (2G9)는 인간 BUBR1 단백질을 인식하는 Mouse IgG1 항체입니다. Western blot 및 ELISA에 적합하며, 단백질의 세포분열 체크포인트 연구에 활용됩니다. 액상 형태로 보존제 없이 제공되며 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Concentration: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2G9 |
| Immunogen | BUB1B (AAH18739, 1–130 a.a.) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MAAVKKEGGA LSEAMSLEGD EWELSKENVQ PLRQGRIMST LQGALAQESA CNNTLQQQKR AFEYEIRFYT GNDPLDVWDR YISWTEQNYP QGGKESNMST LLERAVEALQ GEKRYYSDPR FLNLWLKLGR
Target Information
BUBR1 is a member of the Ser/Thr protein kinase family and a key component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the spindle. Dysfunction in this checkpoint contributes to genetic instability and cancer progression.
Human cells contain two related kinases, hBUBR1 and hBUB1, which monitor kinetochore-microtubule interactions during mitosis. BUBR1 has been identified as a binding partner of BCSG1 (Breast Cancer-Specific Gene 1), suggesting a role in accelerating breast cancer progression by compromising mitotic checkpoint control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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